Sadaoki Sakai Selected Research

eldecalcitol (ED 71)

1/2019	Histological Effects of the Combined Administration of Eldecalcitol and a Parathyroid Hormone in the Metaphyseal Trabeculae of Ovariectomized Rats.
3/2016	Effects of eldecalcitol on bone and skeletal muscles in glucocorticoid-treated rats.
12/2015	Treatment with the combination of ibandronate plus eldecalcitol has a synergistic effect on inhibition of bone resorption without suppressing bone formation in ovariectomized rats.
10/2014	Eldecalcitol improves mechanical strength of cortical bones by stimulating the periosteal bone formation in the senescence-accelerated SAM/P6 mice - a comparison with alfacalcidol.
4/2013	Sphingosine-1-phosphate-mediated osteoclast precursor monocyte migration is a critical point of control in antibone-resorptive action of active vitamin D.
5/2012	Combination therapy with eldecalcitol and alendronate has therapeutic advantages over monotherapy by improving bone strength.
2/2012	Daily administration of eldecalcitol (ED-71), an active vitamin D analog, increases bone mineral density by suppressing RANKL expression in mouse trabecular bone.

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Sadaoki Sakai Research Topics

Disease

7	Osteoporosis 01/2019 - 01/2009
6	Bone Resorption 01/2019 - 02/2012
2	Metabolic Bone Diseases (Osteopenia) 03/2016 - 04/2011
2	Body Weight (Weight, Body) 02/2012 - 04/2011
1	Atrophy 03/2016
1	Muscular Diseases (Myopathy) 03/2016
1	Bone Fractures (Bone Fracture) 12/2015
1	Hypercalcemia (Milk Alkali Syndrome) 02/2012
1	Bone Diseases (Bone Disease) 01/2009

Drug/Important Bio-Agent (IBA)

7	eldecalcitol (ED 71)IBA 01/2019 - 02/2012
3	Cholecalciferol (Vitamin D3)FDA Link 01/2019 - 12/2015
3	hydroxide ionIBA 10/2014 - 01/2009
2	Prednisolone (Predate)FDA LinkGeneric 03/2016 - 04/2011
2	GlucocorticoidsIBA 03/2016 - 04/2011
2	Vitamin D FDA LinkGeneric 12/2015 - 04/2013
2	alfacalcidolIBA 10/2014 - 05/2012
1	Anabolic AgentsIBA 01/2019
1	Teriparatide (Parathar)FDA Link 01/2019
1	Parathyroid Hormone (Parathormone)IBA 01/2019
1	Ibandronic Acid (Boniva)FDA Link 12/2015
1	Diphosphonates (Bisphosphonates)IBA 12/2015
1	salicylhydroxamic acid (SHAM)IBA 12/2015
1	Pharmacologic ActionsIBA 04/2013
1	Calcitriol (Calcijex)FDA LinkGeneric 04/2013
1	Alendronate (Alendronate Sodium)FDA LinkGeneric 05/2012
1	Estrogens (Estrogen)FDA Link 05/2012
1	VitaminsIBA 02/2012

Therapy/Procedure

1	Therapeutics 01/2009